Bromine and thyroid hormone activity.

Bromine and thyroid hormone activity.

AIMS To examine the possible consequences of high plasma concentrations of bromine on thyroid hormone. METHODS Bromine was measured by inductively coupled plasma mass spectrometry in the plasma of 799 patients consulting for thyroid disorders. Because the mean (SD) bromine concentration in the plasma of healthy subjects is 4 (1) mg/l, concentrations above 6 mg/l were regarded as outside the n...

Catecholamine-thyroid hormone interactions: II. Thyroid hormone and platelet MAO activity in patients with thyroid disorders.

Platelet monoamine oxidase (MAO) activity and serum thyroxine indices were determined in 62 children and adolescents currently undergoing medical treatment for various thyroid disorders. The platelet MAO activity of these patients was similar to that of control and contrast groups previously reported, and there were no differences when patients were grouped according to specific thyroid disorde...

Catecholamine-thyroid hormone interactions: I. Thyroid hormone and platelet MAO activity in psychiatrically disturbed children.

Thyroid hormones are intimately related to mood and behavior, as is vividly evident in the anxiety and agitation of hyperthyroidism and the lethargy of the hypothyroid state. Extremes of activity (augmented or reduced) seen in severe developmental disturbances are often target symptoms for medication, and triidothyronine (T3) has been used in the treatment of childhood psychoses with a benefici...

Thiazolidinediones with thyroid hormone receptor agonistic activity.

Several thiazolidinedione derivatives (3-7) were designed and synthesized as candidate thyromimetic drugs. Among them, the dihydrogenated compounds, such as 5-2-[[4-(3-tert-butyl-4-hydroxyphenyl)oxy-3,5-diiodophenyl] ethyl]-2,4-thiazolidinedione (6b) and its 3-isopropyl analog (7b), exhibited potent thyroid hormone receptor alpha 1 (TR alpha 1) activation activity.

Thyroid Stimulating Hormone Thyroid Stimulating Hormone